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Effectiveness of Therapies for GERD
Class of Drugs How It Works Eliminate Symptoms Heal Esophagitis Manage or Prevent Complications Maintain Remission
Antacids neutralize acid +1 0 0 0
H2 Blockers Over-the-counter mildly suppress acid +1 0 0 0
Promotility increase LES pressure; move acid from esophagus and stomach +2 +1 0 +1
H2 Blockers Prescription moderately suppress acid +2 +2 +1 +1
H2 Blockers + Promotility moderately suppress acid; move acid from esophagus and stomach +3 +3 +1 +1
High Dose H2 Blockers moderately suppress acid +3 +3 +2 +2
Proton Pump Inhibitors markedly suppress acid +4 +4 +3 +4
Surgery improve barrier between stomach and esophagus to prevent acid reflux +4 +4 +3 +4

Rating Scale: 0 (no effect) to +4 (nearly 100%)

From An Update on GERD Educational Slide Lecture program, © 1996 ACG.


 
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